OxyContin oxycodone Opioid Pain Medication Side Effects & Dosage

This risk is increased with concurrent abuse of OXYCONTIN with alcohol and/or other CNS depressants see Warnings and Precautions (5.1, 5.3), Drug Interactions (7). The following adverse reactions have been identified during post-approval use of extended-release oxycodone. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Health & Wellness

• Compared to young adults, the plasma concentrations of oxycodone were increased approximately 15% see Clinical Pharmacology (12.3).
• However, abuse of OXYCONTIN by these routes, as well as by the oral route, is still possible.
• Employ other supportive measures (including oxygen, vasopressors) in the management of circulatory shock and pulmonary edema as indicated.
• Oxycodone is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated.

The most frequent adverse events observed in pediatric patients were vomiting, nausea, headache, pyrexia, and constipation see DOSAGE AND ADMINISTRATION, ADVERSE REACTIONS, CLINICAL PHARMACOLOGY and Clinical Studies. Tolerance is a physiological state characterized by a reduced response to a drug after repeated administration (i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose). Both tolerance and physical dependence can develop during use of opioid therapy. The in vitro data demonstrate that OXYCONTIN has physicochemical properties expected to make abuse via injection difficult. Table 4 includes clinically significant drug interactions with OXYCONTIN.

Drug Label Info

However, severe withdrawal symptoms can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in OXYCONTIN-treated patients may increase oxycodone plasma concentrations and prolong opioid adverse reactions. When using OXYCONTIN with CYP3A4 inhibitors or discontinuing CYP3A4 inducers in OXYCONTIN-treated patients, evaluate patients at frequent intervals and consider dosage reduction of OXYCONTIN until stable drug effects are achieved see Drug Interactions (7). When using OXYCONTIN with CYP3A4 inhibitors or discontinuing CYP3A4 inducers in OXYCONTIN-treated patients, evaluate patients at frequent intervals and consider dosage reduction of OXYCONTIN until stable drug effects are achieved.

Purdue’s Response

In open-label studies of cancer pain, 187 patients received OXYCONTIN in total daily doses ranging from 20 mg to 640 mg per day. There are no well-controlled clinical Alcoholics Anonymous studies evaluating the safety and efficacy with dosing more frequently than every 12 hours. As a guideline for pediatric patients 11 years and older, the total daily oxycodone dosage usually can be increased by 25% of the current total daily dosage. As a guideline for adults, the total daily oxycodone dosage usually can be increased by 25% to 50% of the current total daily dosage, each time an increase is clinically indicated. Monitor patients receiving OXYCONTIN and any CYP3A4 inhibitor or inducer see WARNINGS AND PRECAUTIONS , DRUG INTERACTIONS , CLINICAL PHARMACOLOGY.

Keep this medication in the container it came in, tightly closed, and out of reach of children, and in a location that is not easily accessible by others, including visitors to the home. Store it at room temperature and away from light and excess heat and moisture (not in the bathroom). Call your doctor if you have any unusual problems while you are taking this medication.

Tell your health care how addictive is oxycontin provider if you have any of the following symptoms of adrenal insufficiency. In some cases, medication-assisted treatment (MAT) may be recommended. MAT combines medication, such as buprenorphine or methadone, with counseling and behavioral therapies to manage cravings and reduce the risk of relapse.